Originally from Sydney, Australia, Luke Hume moved to New York City where he began playing Rugby League for the New Your Knights. In 2009, his first year with the team, Hume led the Knights to a league championship and was awarded AMNRL MVP.
Hume played Rugby Union for Old Blue in New York and in 2012 he made his debut for both the Men's Eagles and Men's Eagles Sevens. Hume scored a try in his first XV appearance (Canada). He also helped the USA qualify for the 2013 Rugby World Cup Sevens and was subsequently signed to a contract to train with the Men's Sevens.
In August 2013, Hume played for Gloucester A as part of a trial but left without a contract. The next year, he signed and played for RC Narbonne before his season was cut short due to injury.
Hume returned to the pitch as a member of the Men's Eagles in the 2016 Americas Rugby Championship, scoring a try in his second appearance (vs. Chile).